Initial Injury:1 day after SCI. All mice show a lack of movement in the hind legs.


Control Group: 8 weeks after SCI. This mouse is the control group (did not receive the treatment). This mouse displays movement of their hind legs, but could not support their own weight.

Test Group: 8 weeks after SCI. This mouse received the treatment of NSC and could not only move their legs, but could also touch the ground with their paws and/or support their body weight.

 Mice Experiment:

            In this experiment, the scientists created a spinal cord injury (SCI) in mice and transplanted stem cells to restore motor function. SCI is one of the most common reasons for loss of movement and sensation below the injury to the spinal cord. Scientists have been successful in inserting neural stem cells (NSCs) to an injured spinal cord to help regain function. The stem cells they have used, however, have been from either human fetal tissue (a source is aborted babies) or embryotic stem cells (fertilized eggs). The usage of these stem cells has caused multiple ethical issues, so the scientists in this experiment discovered a way to take an adult cell and change its characteristics into the specialty that is needed. These scientists have developed human induced pluripotent stem cells (iPSCs) which are generated from adult tissue cells and create NSCs. These iPSCs can be created from the injured patient to help reduce the risk of host immune rejection and help reduce ethical concerns of farming embryos or dissecting aborted babies. The scientists in this study took human NSCs derived from iPSCs, and inserted the new cells into the spinal cord of a mouse. They conducted this study with the belief that the “cells...have a therapeutic potential comparable to that of [neural stem cells] from human fetal spinal cord...for SCI in the non-obese diabetic-severe combined immunodeficient...mouse model” and they were successful.



Yusuke Fujimoto, Masahiko Abematsu, Anna Falk, Keita Tsujimura, Tsukasa Sanosaka, Berry

Juliandi, Katsunori Semi, Masakazu Namihira

, Setsuro Komiya, Austin Smith, Kinichi Nakashim

 A- The survival of the transplanted cells was checked every week using a 

bioluminescence imaging system; left, 2 hours after transplantation; middle, 4 weeks after SCI; right, 
8 weeks after SCI.

 B- Time course of transplanted hiPS-lt-NES cell survival in SCI model mice. 

Optical signal intensity was measured using the bioluminescence imaging system. Quantification of 
the photon intensity revealed that about 20% of the transplanted cells survived 5 weeks after SCI; 
thereafter, the photon signals remained stable. Data are means ± SEM (n = 6).

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